Students are required to earn three units of credit in mathematics to graduate from Buffalo Grove High School. One credit must be in algebra and one in geometry. Honors students start with geometry and general education students start with algebra as freshmen, swapping this focus for sophomore year. As juniors, students either take an additional algebra course or move on to pre-calculus. Then, as seniors, students can enroll in Advanced Placement calculus, college algebra or a course in college mathematical applications. Advanced Placement statistics serves as an additional mathematics elective and students also have the opportunity to take College Calculus 3 and Differential Equations.

Students must earn at least two units of credit in science to qualify for graduation. Freshmen start with biology and then move on to chemistry as sophomores before taking physics as juniors. Senior year is open for students to choose from a range of electives, including human physiology, college physical science, the medical science academy, and advanced placement courses in physics, biology, environmental science, and chemistry.